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US 12,472,280 B2Granted
Manufacture of photo-crosslinkable biodegradable tissue adhesive using copolymer
AssigneeSnvia Co., Ltd.
InventorsSeung Yun Yang, Samdae Park, Hyeseon Lee
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Abstract
The present invention relates to the manufacture of a photo-crosslinkable biodegradable tissue adhesive using a multinetwork-forming copolymer, and provides a hyaluronic acid copolymer compound having excellent elongation, mechanical properties, and tissue adhesion. The compound fundamentally does not undergo phase separation, and enables the manufacture of a tissue adhesive with desired adhesive characteristics and physical characteristics.
Claims6
A compound represented by Chemical Formula 1:
- wherein, in Chemical Formula 1,
- m is an integer of 1 to 10,000 and n is an integer of 1 to 10,000,
- a ratio of m and n is 9:1 to 7:3,
- X1, X2, X3, and X4 are each independently a hydroxyl group or a substituent represented by Chemical Formula 1-1, provided that at least one of X1-X4 is the substituent represented by Chemical Formula 1-1,
- X5, X6, X7, and X8 are each independently a hydroxyl group or a substituent represented by Chemical Formula 1-2, provided that at least one of X5-X8 is the substituent represented by Chemical Formula 1-2,
- in Chemical Formula 1-1, p1 is 1, and q1 is 1,
- in Chemical Formula 1-2, p2 is 2 to 10, and q2 is 0.
4 more elements
Dependencies are inferred from the claim text.