Glyconjugate vaccines
AssigneesUCL Business PLC, London School of Hygiene and Tropical Medicine
InventorsBrendan Wren, Jeremy Brown, Jon Cuccui
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Abstract
This invention relates to the use of S. pneumoniae protein antigens, such as NanA, PiuA and Sp0148, as carriers for immunogenic S. pneumoniae capsular polysaccharide. This may be useful for example in glycoconjugate vaccines able to generate a protective immune response against multiple capsular serotypes. Glycoconjugates, vaccine compositions and methods of manufacture and use are provided.
Claims7
A glycoconjugate comprising an isolated S. pneumoniae protein antigen glycosylated with an isolated S. pneumoniae capsular polysaccharide, wherein the isolated protein antigen is S. pneumoniae Sp0148 protein antigen comprising an amino acid sequence having at least 80% sequence identity to SEQ ID NO:
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Dependencies are inferred from the claim text.