Antibodies against fentanyl and fentanyl analogs
AssigneesThe Government of the United States, as represented by the Secretary of the Army, The United States of America, as represented by the Secretary, Department of Health Bethesda, MD
InventorsGary R. Matyas, Rodell C. Barrientos, Oscar B. Torres, Connor Whalen, Therese Oertel, Kenner C. Rice, Arthur E. Jacobson, Eric W. Bow, Agnieszka Sulima
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Abstract
The present disclosure is directed to isolated recombinant antibodies, or antigen-binding fragments thereof, that bind to fentanyl or fentanyl analogs. The novel antibodies or antigen-binding fragments thereof can be used to detect, diagnose, treat, and/or prevent opioid use disorder.
Claims14
An isolated recombinant monoclonal antibody, or an antigen-binding fragment thereof, that binds to fentanyl or a fentanyl analog, wherein said antibody comprises a heavy chain variable domain and a light chain variable domain,
- (1) wherein the heavy chain variable domain comprises a complementarity determining region 1 (CDR1) comprising the amino acid sequence of SEQ ID NO:
- 3;
- a CDR2 comprising the amino acid sequence of SEQ ID NO:4;
- and a CDR3 comprising the amino acid sequence of SEQ ID NO:5;
- and wherein the light chain variable domain comprises:
- a CDR1 comprising the amino acid sequence of SEQ ID NO:6;
- a CDR2 comprising the amino acid sequence of SEQ ID NO:
- 7;
- and a CDR3 comprising the amino acid sequence of SEQ ID NO:8;
- or
- (2) wherein the heavy chain variable domain comprises a complementarity determining region 1 (CDR1) comprising the amino acid sequence of SEQ ID NO:
- 11;
- a CDR2 comprising the amino acid sequence of SEQ ID NO:12;
- and a CDR3 comprising the amino acid sequence of SEQ ID NO:13;
- and wherein the light chain variable domain comprises:
- a CDR1 comprising the amino acid sequence of SEQ ID NO:14;
- a CDR2 comprising the amino acid sequence of SEQ ID NO:15;
- and a CDR3 comprising the amino acid sequence of SEQ ID NO:
- 16.
Dependencies are inferred from the claim text.