Immunogenic compositions and uses thereof
AssigneeBoard of Regents, The University of Texas System
InventorsMaria A. Croyle, Stephen Clay Schafer
Life of this patent
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Abstract
Immunogenic compositions comprising viral vectors and surfactants are provided. Methods for administration and preparation of such compositions are also provided.
Claims24
A method for providing an immune response in a mammal, comprising:
- obtaining a composition comprising a recombinant viral vector in a pharmaceutically acceptable carrier, said carrier comprising:
- (i) PMAL-C16;
- or
- (ii) from about 0.1% to 10% of a zwitterionic surfactant;
- or
- (ii) from about 0.1 to 50 mg/ml of a zwitterionic surfactant;
- and
- administering an effective amount to the composition to a subject;
- wherein the subject has been previously exposed to a virus that cross reacts antigenically with the viral vector of the composition.
A method for providing an immune response in a mammal comprising, administering to the primate an effective amount of a recombinant viral vector formulated in a pharmaceutically acceptable liquid carrier comprising:
- (i) PMAL-C16;
- or
- (ii) from about 0.1% to 10% of a zwitterionic surfactant;
- or
- (ii) from about 0.1 to 50 mg/ml of a zwitterionic surfactant.
A method for providing an immune response in a mammal, comprising:
- obtaining a composition comprising an antigen in a pharmaceutically acceptable carrier, said carrier comprising:
- (i) PMAL-C16;
- or
- (ii) from about 0.1% to 10% of a zwitterionic surfactant;
- or
- (ii) from about 0.1 to 50 mg/ml of a zwitterionic surfactant;
- and
- administering an effective amount to the composition to a subject.
A method for providing an immune response in a mammal comprising, administering to the primate an effective amount of an antigen formulated in a pharmaceutically acceptable liquid carrier comprising:
- (i) PMAL-C16;
- or
- (ii) from about 0.1% to 10% of a zwitterionic surfactant;
- or
- (ii) from about 0.1 to 50 mg/ml of a zwitterionic surfactant.
Dependencies are inferred from the claim text.