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US 12,472,241 B2Granted
Treatment of respiratory disorders with arachidonate 15-lipoxygenase (ALOX15) inhibitors
AssigneeRegeneron Pharmaceuticals, Inc.
InventorsJulie Horowitz, Aris Baras
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Abstract
The present disclosure provides methods of treating patients having a respiratory disorder, methods of identifying subjects having an increased risk of developing a respiratory disorder, and methods of detecting human Arachidonate 15-Lipoxygenase (ALOX15) variant nucleic acid molecules and variant polypeptides.
Claims7
A method of treating a patient having a nasal polyp, allergic rhinitis, asthma, and/or aspirin-exacerbated respiratory disease (AERD), the method comprising administering an Arachidonate 15-Lipoxygenase (ALOX15) inhibitor to the patient,
- wherein the ALOX15 inhibitor comprises an ALOX15 antisense molecule;
- wherein the patient is heterozygous or reference for ALOX15 Thr560Met;
- and
- wherein the patient is reference for ALOX15, Leu651fs, Asn658Lys, Val474Ala, and/or Leu106fs.
1 more element
Dependencies are inferred from the claim text.