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US 12,472,167 B2Granted
Methods providing a therapeutic macromolecule and synthetic nanocarriers comprising immunosuppressant locally and concomitantly to reduce both Type 1 and Type IV hypersensitivity
AssigneeCartesian Therapeutics, Inc.
InventorRoberto A. Maldonado
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Abstract
Disclosed are methods and related compositions for concomitantly, locally administering immunosuppressants and doses of therapeutic macromolecules for reducing Type I and Type IV hypersensitivity.
Claims20
A method comprising:
- providing a therapeutic dose of a therapeutic macromolecule, wherein the therapeutic macromolecule is not attached to synthetic nanocarriers;
- providing a composition comprising synthetic nanocarriers that are attached to immunosuppressants;
- and
- administering the composition and the therapeutic dose of the therapeutic macromolecule to a subject concomitantly,
- and
- wherein the concomitant administration of the composition and the therapeutic dose of the therapeutic macromolecule reduces both Type 1 hypersensitivity and Type IV hypersensitivity in the subject.
3 more elements
Dependencies are inferred from the claim text.