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US 12,472,161 B2Granted
Storage stable mixtures, method of improving retention of a compound and use of rice hulls and/or rice bran to enhance retention of a compound
AssigneeDsm IP Assets B.V.
InventorsDominik Josef Brunner, Laure Clasadonte, Martin Reto Gadient, Roland Schuepfer
Life of this patent
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Abstract
The present invention relates to improved formulations of propandiol mononitrate and derivatives thereof as well as to the production of such formulations.
Claims21
A storage stable mixture comprising:
- (a) a powderous formulation;
- and
- (b) rice hulls and/or rice bran;
- wherein the powderous formulation comprises:
- (i) silica, and
- (ii) 1,3-propanediol mononitrate (PDMN) as an active ingredient absorbed on the silica;
- and
- wherein the rice hulls and/or rice bran are present in an amount to provide a weight ratio (w/w) of the rice hulls and/or rice bran to the PDMN active ingredient of 200:1 to 1:1 sufficient to reduce evaporation and thereby provide a retention of the PDMN active ingredient in the powderous formulation which is at least 70% when stored in a closed polyethylene or aluminum bag for at least 4 weeks at 25° C. and 50% relative humidity.
5 more elements
A method of improving retention of propanediol mononitrate in a powderous formulation comprising the propanediol mononitrate, the method comprising the steps of:
- (a) providing a powderous formulation comprising silica and 1,3-propanediol mononitrate (PDMN) as an active ingredient absorbed on the silica, and
- (b) admixing the powderous formulation comprising the silica and PDMN active ingredient absorbed on the silica with rice hulls and/or rice bran in amounts so as to achieve a weight ratio (w/w) of the rice hulls and/or the rice bran to the powderous formulation in a range of 50:1 to 1:10 and to achieve a weight ratio (w/w) of the rice hulls and/or rice bran to the PDMN active ingredient of 200:1 to 1:1 sufficient to reduce evaporation and thereby provide a retention of the PDMN active ingredient in the powderous formulation which is at least 70% when stored in a closed polyethylene or aluminum bag for at least 4 weeks at 25° C. and 50% relative humidity.
Dependencies are inferred from the claim text.