Blend compositions for oral administration as a rapidly dissolving powder and/or suspension
AssigneeMarenda Pharmaceuticals LLC
InventorsAndrew Favara, Marc Karetny
Life of this patent
Estimating the term…
Abstract
Disclosed is a dry powder oral formulation that includes an active pharmaceutical ingredient (API), a lecithin powder, a galactomannan, one or more sweetening agents, one or more flavoring agents and an organic acid in a pharmaceutically acceptable preparation. Also disclosed are an excipient composition in absence of an API and methods of making and using the formulations and compositions. Also disclosed is a chewable, swallowable, and/or orally disintegrating tablet comprising an API, a lecithin powder, a galactomannan, one or more sweetening agents, one or more flavoring agents and an organic acid in a pharmaceutically acceptable preparation.
Claims19
A free-flowing dry powder oral formulation suitable for administration in each of an aqueous solution, aqueous dispersion, tablet, and powder dosage form,
- wherein the formulation comprises an active pharmaceutical ingredient (API) in an amount from about 3% w/w to about 15% w/w,
- lecithin powder in an amount from 0.1% w/w to 1% w/w,
- a galactomannan in an amount from about 0.05% w/w to about 0.5% w/w,
- at least one sweetening agent in an amount of 81.125% w/w,
- one or more diluents in an amount up to about 90% w/w,
- one or more flavoring agents in an amount from about 0.5% w/w to about 5% w/w and an organic acid in an amount from about 0.05% w/w to about 0.5% w/w, in a pharmaceutically acceptable preparation.
A formulation suitable for oral administration in a unit dosage form selected from powder, granulation, tablet, sphere, or capsule,
- wherein the formulation comprises an active pharmaceutical ingredient (API) in an
- amount from about 3% w/w to about 15% w/w, lecithin powder in an amount from 0.1% w/w to 1% w/w, a galactomannan in an amount from about 0.05% w/w to about 0.5% w/w, one or more sweetening agents in an amount of 81.125% w/w, one or more diluents in an amount up to about 90% w/w, one or more flavoring agents in an amount from about 0.5% w/w to about 5% w/w and an organic acid in an amount from about 0.05% w/w to about 0.5% w/w, in a pharmaceutically acceptable preparation.
A method of preparing a dry powder oral formulation of an API suitable for administration in each of an aqueous solution, aqueous dispersion, tablet, and powder dosage form, the method comprising, combining, in any order,
- a) an API in an amount from about 3% w/w to about 15% w/w,
- b) lecithin powder in an amount from 0.1% w/w to 1% w/w,
- c) a galactomannan in an amount from about 0.05% w/w to about 0.5% w/w,
- d) one or more sweetening agents in an amount of 81.125% w/w,
- e) one or more flavoring agents in an amount from about 0.5% w/w to about 5% w/w,
- f) an organic acid in an amount from about 0.05% w/w to about 0.5% w/w, and
- q) one or more diluents in an amount up to about 90% w/w.
Dependencies are inferred from the claim text.