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US 12,467,065 B2Granted
Recombinant adeno-associated virus capsids with enhanced human pancreatic tropism
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsKatja Pekrun, Mark A. Kay
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Abstract
The present invention relates to variant AAV capsid polypeptides, wherein the variant AAV capsid polypeptides exhibit increased transduction and/or tropism in human pancreatic tissue or human islets as compared non-variant parent capsid polypeptides.
Claims2
A method of using an AAV capsid polypeptide to deliver a nucleic acid to a subject, the method comprising the step of administering to the subject an AAV vector whose genome comprises the nucleic acid,
- wherein the AAV capsid polypeptide is part of a functional AAV capsid,
- wherein the functional AAV capsid packages a nucleic acid sequence, and
- wherein the AAV capsid polypeptide sequence has the amino acid sequence selected from the group consisting of AAV-10A1 (SEQ ID NO:
- 1), AAV-10A3 (SEQ ID NO:2), AAV-10A4 (SEQ ID NO:3), AAV-10A5 (SEQ ID NO:4), AAV-18A1 (SEQ ID NO:5), AAV-10B1 (SEQ ID NO:6), AAV-10B3 (SEQ ID NO:7), AAV-10B5 (SEQ ID NO:8), AAV-10B6 (SEQ ID NO:9), AAV-10B7 (SEQ ID NO:10), AAV-18B2 (SEQ ID NO:12), and AAV-18B3 (SEQ ID NO:13).
1 more element
Dependencies are inferred from the claim text.