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US 12,467,064 B2Granted
Artificial expression constructs for selectively modulating gene expression in interneurons
AssigneesAllen Institute, Seattle Children's Hospital
InventorsJonathan Ting, Boaz P. Levi, John K. Mich, Edward Sebastian Lein, Franck Kalume
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Abstract
Artificial expression constructs for selectively modulating gene expression in selected central nervous system cell types are described. The artificial expression constructs can be used to selectively express synthetic genes or modify gene expression in GABAergic interneurons.
Claims18
An artificial expression construct comprising (i) a concatemer comprising 2, 3, 4, 5, 6, 7, 8, 9, or 10 copies of a sequence consisting of SEQ ID NO:
- 2 or SEQ ID NO:
- 6;
- (ii) a promoter;
- and (iii) a coding sequence.
1 more element
Dependencies are inferred from the claim text.