Methods for activation and expansion of natural killer cells and uses thereof
AssigneeBoard of Regents, The University of Texas System
InventorsLucila Nassif Kerbauy, Elizabeth Shpall, Katy Rezvani
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Abstract
Provided herein are methods for pre-activating and expanding an isolated population of NK cells. Further provided herein are methods for the treatment of cancer by administering the pre-activated and expanded NK cells.
Claims10
A method for treating cancer in an individual in need thereof, comprising administering to the individual in need thereof a therapeutically effective amount of ex vivo-combined pre-activated NK cells and a monoclonal, bispecific, or trispecific antibody, wherein the antibody binds an NK cell receptor to redirect the NK cells to a target tumor cell, wherein
- (a) the NK cells are produced by the step of pre-activating the population of NK cells in a pre-activation culture comprising an effective concentration of IL-12, IL-15, and IL-18 to obtain pre-activated NK cells and then
- (b) expanding the pre-activated NK cells in an expansion culture comprising artificial antigen presenting cells (aAPCs) expressing CD 137 ligand.
Dependencies are inferred from the claim text.