Method and kit for treating a neurodegenerative disease
AssigneeThe Board of Trustees of the University of Illinois
InventorsJeffrey A. Loeb, Fei Song
Life of this patent
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Abstract
A method and kit for treating a neurodegenerative disease or central nervous system disorder in a subject using a GlyB4 fusion protein is provided, as is a kit containing the same.
Claims7
A method of reducing amyloid β plaque formation in a subject comprising administering to the subject in need of treatment an effective amount of GlyB4 fusion protein consisting of SEQ ID NO:
- 1, wherein the GlyB4 fusion protein penetrates the central nervous system thereby reducing amyloid β plaque formation.
A method of treating Alzheimer's disease in a subject comprising administering to the subject in need of treatment an effective amount of a composition formulated for intraventricular or intrathecal delivery of a GlyB4 fusion protein consisting of SEQ ID NO:
- 1, wherein said composition penetrates the brain and blocks brain inflammation and/or reduces amyloid β plaque formation thereby treating the subject's Alzheimer's disease.
A method of reducing brain inflammation in a subject comprising administering to the subject in need of treatment an effective amount of GlyB4 fusion protein consisting of SEQ ID NO:1, wherein the GlyB4 fusion protein penetrates the central nervous system thereby reducing brain inflammation in the subject.
Dependencies are inferred from the claim text.