Desmoglein 2 (DSG2) binding proteins and uses therefor

A method for enhancing access to epithelial cells, the method comprising administering to a subject with a disorder associated with epithelial cells:

• a) a cellular immunotherapy agent;
• and
• b) a recombinant AdB-⅔ fiber polypeptide, comprising:
• one or more AdB-⅔ fiber polypeptide shaft domain motifs;
• an AdB-⅔ fiber polypeptide knob domain operatively linked to and located C-terminal to the one or more AdB-⅔ fiber polypeptide shaft domain motifs,
• wherein the AdB-⅔ fiber polypeptide knob domain comprises the peptide of SEQ ID NO:
• 4 wherein:
• X2 is H, L, or P;
• X3 is K or E;
• X4 is T, F, S, or L;
• X5 is V, or D;
• X6 is E or G;
• X7 is Y or F;
• X8 is T, K, or E;
• and
• X9 is N or S;
• and
• wherein at least one of the following is true:
• X2 is P;
• X3 is E;
• X4 is S, or L;
• X5 is D;
• X6 is G;
• X7 is F;
• X8 is E;
• or X9 is S;
• and
• one or more non-AdB-⅔-derived dimerization domains operatively linked to and located N-terminal to the one or more AdB-⅔ fiber polypeptide shaft domain motifs.