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US 12,466,843 B2Granted
Gadolinium-based compound, method for producing same, and MRI contrast agent containing same
AssigneeKyungpook National University Industry-Academic Cooperation Foundation
InventorsYong Min Chang, So Yeon Kim
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Abstract
The present invention relates to a gadolinium-based compound of a Chemical Formula 1, a method for producing the same, and an MRI contrast agent containing the same. [Chemical Formula 1] [structural formula] In chemical formula 1, A and Linker represent linking groups, and RB represents a Rose Bengal-derived part.
Claims20
A gadolinium-based compound represented by a following Chemical Formula 1:
- wherein in the Chemical Formula 1,
- A represents *—(CH2)n-A1-*,
- n represents any integer from 0 to 5,
- A1 represents *—COO—*, *—CO—*, *—NR1—*, *—CH2—*, *—CONH—*, or *—O—*,
- Linker represents *-L1-NHCO-L2-*, *-L1-O—R2—O-L2-*, *-L1-CH2-L2-*, *-L1-NR3-L2-* or *-L1-COO-L2-*,
- each of L1 and L2 independently represents linear or branched (C1-C30)alkyl,
- each of R1 and R3 independently represents hydrogen or linear or branched (C1-C10)alkyl,
- R2 represents linear or branched (C1-C20)alkyl,
- RB represents a following Chemical Formula 2:
- * indicates a connection site,
- wherein the gadolinium-based compound is capable of binding vesicular glutamate transporter (VGLUT).
8 more elements
Dependencies are inferred from the claim text.