Tricyclic compounds with OMA1/OPA1 modulatory properties

A compound of formula (I)

• or a stereochemical isomeric form thereof, wherein
• A is an alkyl, alkylene, alkenyl, alkynyl, alkylidene, —N(H)—, —N(R11)—, —N(OH)—, —S(O)2—, —S(O)—, —O—, or the like;
• B is C, N, O, P, or S provided that when B represents N or O then B may or may not be substituted at R6;
• R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, or R12 is hydrogen, halo, hydroxy, carboxy, keto, alkyl, alkylene, haloalkyl, polyhaloalkyl, haloalkoxy, nitrile, carbocyclic residue, aryl, aryloxy, arylamino, arylalkylamino, arylthio, arylalkanoylamino, arylsulfonyl, arylalkoxy, arylsulfinyl, arylheteroaryl, arylalkylthio, arylcarbonyl, arylalkenyl, or arylalkylsulfonyl, alkynyl, alkenyl, alkyloxy, polyhaloalkyloxy, alkylidene, cycloalkyl, cycloalkanone, heterocyclic group, heteroaryl, —C(O)OR12, —NR13R14, —C(O)NR13R14 or the like, wherein NR13R14 may form a heterocyclic ring, or a chemical group;
• and wherein at least one of R1, R2, R3, R4, R7, R8, R9, or R10 is a group of formula (II)
• or a stereochemical isomeric form thereof, wherein
• A′ is a sulfonyl group (—S(O)2—);
• B′ is N, O, P or S;
• and
• R′1 or R′2 is hydrogen, halo, hydroxy, carboxy, keto, alkyl, alkylene, haloalkyl, polyhaloalkyl, haloalkoxy, nitrile, carbocyclic residue, aryl, aryloxy, arylamino, arylalkylamino, arylthio, arylalkanoylamino, arylsulfonyl, arylalkoxy, arylsulfinyl, arylheteroaryl, arylalkylthio, arylcarbonyl, arylalkenyl, or arylalkylsulfonyl, alkynyl, alkenyl, alkyloxy, polyhaloalkyloxy, alkylidene, cycloalkyl, cycloalkanone, heterocyclic group, heteroaryl, —C(O)OR12, —NR13R14, —C(O)NR13R14 or the like, wherein NR13R14 may form a heterocyclic ring, or a chemical group;
• or a pharmaceutically acceptable salt thereof, or an N-oxide thereof.