Back to results
US 12,466,792 B2Granted
Compounds for the treatment of SARS
AssigneePurdue Research Foundation
InventorsArun K. Ghosh, Monika Yadav, Andrew Mesecar
Life of this patent
Estimating the term…
Abstract
Inhibitors of SARS-COV-2 (COVID), pharmaceutical compositions comprising same; and methods of treating a severe acute respiratory syndrome.
Claims13
A compound of the formula (I):
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 —O-1 to 4 carbon alkylene-6 to 10 membered aryl 6 to 10-membered heterocyclyl with one heteroatom or —O-1 to 4 carbon alkylene-6 to 10-membered heterocyclyl with one heteroatom, wherein the 6 to 10-membered heterocyclyl with one heteroatom is connected via a carbon atom on the 6 to 10-membered heterocyclyl group;
- R2 is alkyl, aryl, substituted aryl;
- R3 is 5-or 6-membered heterocyclyl with one to four heteroatoms, wherein the 5- or 6-membered heterocyclyl with one to four heteroatoms is connected to the —CH2- group via a carbon atom on the 5- or 6-membered heterocyclyl group with one to four heteroatoms;
- R4 is H, alkyl or alkenyl;
- and
- Ra is H or alkyl,
- or a pharmaceutically acceptable salt thereof.
5 more elements
Dependencies are inferred from the claim text.