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US 12,466,790 B1Granted
Bis urea-based organoselenium compound and method for treating cancer
AssigneeImam Mohammad Ibn Saud Islamic University
InventorsTarek Ahmed Yousef, Saad Shaaban, Ahmed A. Al-Karmalawy, Marwa Sharaky, Hussein Ba-Ghazal, Mohamed Alaasar
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Abstract
A method of treating cancer including administering a bis-(organoselanyl urea)aryl agent having a Formula (I) to a subject with cancer. The method includes effective inhibition of growth of cancer cells using the compound of Formula (I) as compared to doxorubicin.
Claims16
A method for inhibiting in vitro growth of a cancer cell of a cancer cell line selected from the group consisting of HN9, HuH7, FaDu, MCF7, HEPG2, A549, HCT116, and A375, comprising:
- contacting the cancer cell with a bis-(organoselanyl urea)aryl agent of formula (I):
- wherein R1 is methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, or t-butyl.
Dependencies are inferred from the claim text.