Process for synthesis of high purity 1-[3-(trifluoromethyl)phenyl]ethanone oxime
AssigneeLaxmi Organic Industries Ltd
InventorsRavi Goenka, Ajay A Audi
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Abstract
A process for preparation of 3-Trifluoromethyl acetophenone oxime of formula I includes reacting an isomeric mixture of halo benzotrifluoride with Mg metal in an organic solvent in presence of a catalyst to obtain a Grignard complex. The Grignard complex is reacted with a ketene in hydrocarbon solvent in presence of transition metal ligand-acid complex to obtain an isomeric mixture of trifluoromethyl acetophenone. Finally, the isomeric mixture of trifluoromethyl acetophenone is reacted with hydroxylamine salt to obtain compound of formula I.
Claims9
A process for preparation of 3-Trifluoromethyl acetophenone oxime of formula I, comprising:
- a) reacting an isomeric mixture of a halo benzotrifluoride of formula Ia with Mg metal in an organic solvent in presence of a catalyst to obtain a Grignard complex of formula Ib, wherein said formulae Ia and Ib are respectively as follows, in which X is halogen:
- b) reacting the Grignard complex of said formula Ib with a ketene of formula Ic in a hydrocarbon solvent in the presence of a transition metal ligand-acid complex to obtain an isomeric mixture of trifluoromethyl acetophenone of formula Id, wherein said formulae Ic and Id are respectively as follows:
- and
- c) reacting the isomeric mixture of trifluoromethyl acetophenone of said formula Id with a hydroxylamine salt to obtain the 3-Trifluoromethyl acetophenone oxime of formula I, wherein said formula I is as follows:
Dependencies are inferred from the claim text.