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US 12,466,784 B2Granted
Analogs of pterostilbene amino acid bearing carbonates for treating a non-alcoholic fatty liver disease and nonalcoholic steatohepatitis
AssigneeApical Molecular Biotech Co., Ltd.
InventorsTai-Huang Kuo, Po-Chuen Shieh, Ming-Long Cheng, Chih-Wei Fu
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Abstract
A series of novel analogs of water soluble pterostilbene amino acid bearing carbonates were synthesized, which show activities in treating a non-alcoholic fatty liver disease and a nonalcoholic steatohepatitis (NASH).
Claims16
A compound having the following formula:
- wherein n is 1 to 3;
- mis 2 to 6;
- Q, X and Y independently are O, S, or NH;
- Ra, Rb, and Rc independently are H, halogen, C1-C6 linear alkyl, C1-C6 linear alkoxy, C3-C6 branched alkyl, C3-C6 branched alkoxy or C1-C6 fluoroalkoxy;
- Rd and Re independently are H, halogen, C1-C6linear alkyl, C1-C6 linear alkoxy, C3-C6 branched alkyl, C3-C6 branched alkoxy or C1-C6 fluoroalkoxy, or Rd and Re are linked to form a ring structure, so that
- wherein j is 1 to 3;
- or
- a pharmaceutically acceptable salt thereof.
5 more elements
Dependencies are inferred from the claim text.