Arylcyclohexylamine derivatives and process for preparing same
AssigneeTechnische Hochschule KöLn
InventorsSherif El Sheikh, Henrik Weber
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Abstract
The present invention relates to the technical field of pharmaceutical synthesis and development of drugs, and to a process for preparing cyclic 2-amino-1-one derivatives and to the reaction products and intermediates obtainable by this process. The present invention further relates to pharmaceutical compositions, in particular drugs or medicaments, comprising the cyclic 2-amino-1-one derivatives and to their use as medicaments, in particular in the prophylactic or therapeutic treatment of diseases of the human or animal body, preferably of neurodegenerative diseases or psychiatric disorders.
Claims9
A process for preparing a cyclic 2-amino-1-one derivative, comprising:
- converting an aromatic acrylic acid derivative into a cyclic 3-ene-2-oxy-1-carboxylic acid derivative via a cyclization reaction, wherein:
- the cyclization reaction is a [4+2]cycloaddition;
- and
- the aromatic acrylic acid derivative is a compound of general formula I:
- wherein,
- R1 is aryl or heteroaryl;
- and
- PG is a protecting group.
Dependencies are inferred from the claim text.