Thyromimetics

A compound having the structure of Formula (I):

• or a pharmaceutically acceptable hydrate, solvate, isotope, or salt thereof, wherein:
• X1 is lower alkyl, lower alkenyl, lower haloalkyl, or halo;
• X2 is lower alkyl, lower alkenyl, lower haloalkyl, or halo;
• Y1 and Y2 are each, independently, H, cyano, halogen, lower alkyl, or lower alkoxy, wherein at least one of Y1 and Y2 is not H;
• R1 is —NR1aR1b or —OR1c;
• R1a and R1b are each, independently, H, lower alkyl, lower alkenyl, lower alkynyl, carbocycle, carbocyclealkyl, heterocycle, or heterocyclealkyl, or R1a and R1b taken together with the nitrogen atom to which they are attached form heterocycle;
• R1c is H, lower alkyl, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl;
• and
• R2 is lower alkyl, lower alkenyl, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl;
• wherein R1a, R1b, R1c, and R2 are each, independently, optionally substituted with one or more halo, lower alkyl, lower haloalkyl, cyano, —OR′, —NR′R″, ═O, ═S, —S(O)2R′ or —S(O)2OR′, wherein R′ and R″ are each, independently, H, lower alkyl, or lower haloalkyl.