Method for evaluating covering state of silicone compound
AssigneeTerumo Kabushiki Kaisha
InventorsTakeshi Sato, Renjo Takama
Life of this patent
Estimating the term…
Abstract
A covering state of a coating layer containing a silicone compound on an inner surface of hollow fiber membranes is evaluated by dissolving the silicone compound and a dyeing agent in an organic solvent and causing the coating solution to pass through the hollow fiber membranes. The covering state of the silicone compound or a crosslinked product is determined by observing a dyed state of a hollow fiber membrane end surface on a coating solution passing start side and a dyed state of a hollow fiber membrane end surface on a coating solution passing end side of the hollow fiber membrane on which the coating layer is formed.
Claims15
A method for evaluating a covering state of a silicone compound on a hollow fiber membrane for treating blood in an oxygenator, comprising the steps of:
- dissolving a silicone compound and a dyeing agent in an organic solvent to prepare a coating solution;
- causing the coating solution to pass through an inner surface of a hollow fiber membrane to form a coating layer containing the silicone compound and/or a crosslinked product of the silicone compound and the dyeing agent on the inner surface;
- and
- evaluating a covering state of the silicone compound/the crosslinked product by observing a dyed state of a hollow fiber membrane end surface on a coating solution passing start side and a dyed state of a hollow fiber membrane end surface on a coating solution passing end side of the hollow fiber membrane on which the coating layer is formed.
A method for evaluating a covering state of a silicone compound on a bundle of a plurality of hollow fiber membranes for treating blood in an oxygenator, comprising the steps of:
- dissolving a silicone compound and a dyeing agent in an organic solvent to prepare a coating solution;
- causing the coating solution to pass through an inner surface of the hollow fiber membranes in the bundle to form a coating layer containing the silicone compound and/or a crosslinked product of the silicone compound and the dyeing agent on the inner surface;
- and
- evaluating a covering state of the silicone compound/the crosslinked product of each hollow fiber membrane by observing a dyed state of a hollow fiber membrane end surface on a coating solution passing start side and a dyed state of a hollow fiber membrane end surface on a coating solution passing end side of the hollow fiber membrane on which the coating layer is formed;
- counting a number of the hollow fiber membranes with the dyed state at their coating solution passing end side;
- and
- calculating a dyeing ratio according to the number of hollow fiber membranes within the bundle which are dyed on the coating solution passing end side and a number of hollow fiber membranes dyed on the coating solution passing start side.
Dependencies are inferred from the claim text.