Dosing mechanism with rotational end stop mechanism for terminating dose dispense

A drug delivery device for selecting and dispensing user-variable doses of a medicament, wherein the drug delivery device comprises a dosing mechanism for a drug delivery device for selecting and dispensing user-variable doses of a medicament, the dosing mechanism comprising:

• a housing;
• a piston rod;
• a driving mechanism for rotating one or both of the piston rod and a movement application component that is directly engaged with the piston rod in a dispense rotational direction with respect to the housing for dose dispense;
• and
• a rotational end stop mechanism for terminating dose dispense, the rotational end stop mechanism comprising:
• a first engagement means that is rotationally fixed with respect to one or both of the piston rod and the movement application component, and
• a second engagement means that is prevented from rotation with respect to the housing in the dispense rotational direction at an end of the dose dispense,
• wherein the second engagement means is not directly engaged with the first engagement means during dose dispense, and
• wherein the second engagement means, at the end of dose dispense, directly engages the first engagement means and constitutes a rotational stop for the first engagement means to prevent the first engagement means from further rotation in the dispense rotational direction with respect to the housing.