Method and apparatus for identifying disruption of a fluid connection between an extracorporeal circuit and a patient circulatory system

A method of detecting a disruption of a fluid connection between an extracorporeal circuit and a patient circulatory system the method comprising:

• (a) monitoring an extracorporeal circuit extending from a patient circulatory system through a patient blood withdrawal site to an extracorporeal blood treatment device and returning to the patient circulatory system through a patient blood delivery site, wherein the extracorporeal circuit comprises a blood withdrawal line extending from the patient blood withdrawal site to the blood treatment device, a blood delivery line extending from the blood treatment device to the patient blood delivery site, and a pump configured to pump blood through at least a portion of the extracorporeal circuit;
• (b) identifying an inharmonic change in flow rate data of a flow in a portion of the extracorporeal circuit;
• (c) detecting a disruption of the fluid connection of the blood delivery line of an extracorporeal circuit and the patient circulatory system, wherein the disruption corresponds to the identified inharmonic change in a flow rate in the portion of the extracorporeal circuit;
• and
• (d) sending a control signal upon the detecting of the disruption of the fluid connection of the blood delivery line of the extracorporeal circuit and the patient circulatory system, the control signal configured to instruct the performance of at least one of activating an alarm unit or stopping the pump.