Back to results
US 12,465,659 B2Granted
Iron(III) complexes having new contrast agent properties, for magnetic resonance imaging
AssigneeCharite-Universitatsmedizin Berlin
InventorsEyk Schellenberger, Ralf Hauptmann, Akvile Häckel, Jing Xie, Jörg Schnorr, Bernd Hamm
Life of this patent
Estimating the term…
Abstract
The invention provides novel iron(III) complexes with formulae (1) and (2). Furthermore, corresponding ligands with formulae (L1) and (L2) for the production of iron(III) complexes are disclosed.
Claims15
An iron(III) complex with formula (1) or (2):
- in which
- m=1 to 5;
- Y1 and Y2, independently of one another, are selected from the group comprising O, NH and NR, wherein R represents C1-C15 alkyl or C3-C10 cycloalkyl;
- Y3 is selected from the group comprising O, NH and NR, wherein R represents C1-C15 alkyl or C3-C10 cycloalkyl;
- Y4 is selected from the group comprising OH, OR, NH2, NHR and NR5R6·, wherein R, R5 and R6 represent C1-C15 alkyl or C3-C10 cycloalkyl and R5 and R6 are selected independently of each other;
- Z represents a bridge in accordance with one of formulae (3) to (10):
- in which
- n=0 to 4;
- o=0 to 4;
- * and *′ represent binding sites for the bridge Z to Y1 and Y2 of formula (1) or Y3 and Y4 of formula (2);
- and
- R1, R2, R3 and R4, independently of one another, are selected from the group comprising H, C1-C15 alkyl and C3-C10 cycloalkyl.
9 more elements
A ligand with formula (L1) or (L2):
- in which
- m=1 to 5;
- Y1 and Y2, independently of one another, are selected from the group comprising O, NH and NR, wherein R represents C1-C15 alkyl or C3-C10 cycloalkyl;
- Y3 is selected from the group comprising O, NH and NR, wherein R represents C1-C15 alkyl or C3-C10 cycloalkyl;
- Y4 is selected from the group comprising OH, OR, NH2, NHR and NR5R6, wherein R, R5 and R6 represent C1-C15 alkyl or C3-C10 cycloalkyl and R5 and R6 are selected independently of each other;
- Z represents a bridge in accordance with one of formulae (3) to (10):
- in which
- n=0 to 4;
- o=0 to 4;
- * and *′ represent binding sites for the bridge Z to Y1 and Y2 of formula (1) or Y3 and Y4 of formula (2);
- and
- R1, R2, R3 and R4, independently of one another, are selected from the group comprising H, C1-C15 alkyl and C3-C10 cycloalkyl;
- with the exception of ligands with formula (L2) in which Z is equal to *—CH2CH2—*′, wherein when Y3 is NH and Y4 is NH2, then Z represents a bridge in accordance with one of formulae (4) to (6):
10 more elements
Dependencies are inferred from the claim text.