Back to results
US 12,465,651 B2Granted
Photodynamic therapy composition
AssigneeCase Western Reserve University
InventorJames Basilion
Life of this patent
Estimating the term…
Abstract
A polymerizable phthalocyanine compound having the formula (I) or a PSMA-targeted phthalocyanine compound conjugate thereof having the formula (V).
Claims8
A PSMA-targeted phthalocyanine compound of formula VII:
- or a pharmaceutically acceptable salt thereof.
A pharmaceutical composition for treating cancer in a subject, the composition comprising a plurality of PSMA-targeted phthalocyanine compounds of formula (VII):
- or a pharmaceutically acceptable salt thereof;
- and wherein the PSMA targeting moiety targets the composition to a PSMA expressing cancer cell.
A method for treating a PSMA expressing cancer in a subject, the method comprising:
- (a) administering to the subject with PSMA expressing cancer a therapeutically effective amount of a pharmaceutical composition, the pharmaceutical composition including a plurality of PSMA-targeted phthalocyanine compounds of formula VII:
- or a pharmaceutically acceptable salt thereof;
- and wherein the PSMA targeting moiety targets the PSMA-targeted phthalocyanine compounds to a PSMA expressing cancer cell;
- (b) detecting PSMA-targeted phthalocyanine compounds bound to and/or complexed with the cancer cells to determine the location and/or distribution of the cancer cells in the subject;
- and
- (c) irradiating the detected PSMA-targeted phthalocyanine compounds, thereby inducing the cytotoxic effects of the phthalocyanine compound on the cancer cells.
3 more elements
Dependencies are inferred from the claim text.