Lipopeptide building blocks and synthetic virus-like particles

Abstract

The present invention relates to a lipopeptide building block consisting of (i) a peptide moiety comprising a coiled coil peptide chain segment, wherein said coiled coil peptide chain segment comprises 3 to 8 repeat units, and wherein said repeat unit consists of the sequence IEKKIE-X0 (SEQ ID NO:58), wherein X0 represents an amino acid; and (ii) a lipid moiety comprising the formula LM-I wherein R1 and R2 are independently C11-15 alkyl, wherein R3 is hydrogen or —C(O)C11-15 alkyl wherein said lipid moiety is linked to said peptide moiety, wherein the wavy line in formula LM-I indicates the linkage site to said peptide moiety, as well as conjugates comprising said lipopeptide building blocks to which antigens are coupled, bundles of such conjugates, synthetic virus-like particles (SVLPs) comprising at least one bundle of conjugates and pharmaceutical compositions comprising the same.

Dependencies are inferred from the claim text.