Phthalazinone based modulators for the treatment of disease

A compound represented by the structure of Formula (II):

• or a pharmaceutically acceptable salt thereof wherein:
• X1 is N;
• R4 is independently selected at each occurrence from (a), (b), and (c):
• (a) halogen, —OR20, —SR20, —N(R20)2, —C(O)R20, —C(O)OR20, —OC(O)R20, —OC(O)N(R20)2, —C(O)N(R20)2, —N(R20)C(O)R20, —N(R20)C(O)OR20, —N(R20)C(O)N(R20)2, —N(R20)S(O)2(R20), —S(O)R20, —S(O)2R20, —S(O)2N(R20)2, —NO2, and —CN;
• (b) C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, —OR20, —SR20, —N(R20)2, —C(O)R20, —C(O)OR20, —OC(O)R20, —OC(O)N(R20)2, —C(O)N(R20)2, —N(R20)C(O)R20, —N(R20)C(O)OR20, —N(R20)C(O)N(R20)2, —N(R20)S(O)2(R20), —S(O)R20, —S(O)2R20, —S(O)2N(R20)2, —NO2, ═S, ═O, and —CN;
• and
• (c) C3-10 carbocycle and 3- to 10-membered heterocycle, any of which is optionally substituted with one or more substituents independently selected from halogen, —OR20, —SR20, —N(R20)2, —C(O)R20, —C(O)OR20, —OC(O)R20, —OC(O)N(R20)2, —C(O)N(R20)2, —N(R20)C(O)R20, —N(R20)C(O)OR20, —N(R20)C(O)N(R20)2, —N(R20)S(O)2(R20), —S(O)R20, —S(O)2R20, —S(O)2N(R20)2, —NO2, ═S, ═O, and —CN;
• R5 is C1-6 alkyl optionally substituted with one or more substituents independently selected from:
• halogen, —OR21, —SR21, —N(R21)2, —C(O)R21, —C(O)OR21, —OC(O)R21, —OC(O)N(R21)2, —C(O)N(R21)2, —N(R21)C(O)R21, —N(R21)C(O)OR21, —N(R21)C(O)N(R21)2, —N(R21)S(O)2(R21), —S(O)R21, —S(O)2R21, —S(O)2N(R21)2, —NO2, ═S, ═O, and —CN;
• R6 is independently selected at each occurrence from:
• C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, —OR22, —SR22, —N(R22)2, —C(O)R22,—C(O)OR22, —OC(O)R22, —OC(O)N(R22)2, —C(O)N(R22)2, —N(R22)C(O)R22, —N(R22)C(O)OR22, —N(R22)C(O)N(R22)2, —N(R22)S(O)2(R22), —S(O)R22, —S(O)2R22, —S(O)2N(R22)2, —NO2, ═S, ═O, and —CN;
• Ring B is selected from C3-10 carbocycle and 3- to 10-membered heterocycle;
• R7 is independently selected at each occurrence from:
• halogen, —OR23, —SR23, —N(R23)2, —C(O)R23, —OC(O)R23, —OC(O)N(R23)2, —C(O)N(R23)2, —N(R23)C(O)R23, —N(R23)C(O)OR23, —N(R23)C(O)N(R23)2, —N(R23)S(O)2(R23), —S(O)R23, —S(O)2R23, —S(O)2N(R23)2, —NO2, and —CN;
• and C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, —OR23, —SR23, —N(R23)2, —C(O)R23, —C(O)OR23, —OC(O)R23, —OC(O)N(R23)2, —C(O)N(R23)2, —N(R23)C(O)R23, —N(R23)C(O)OR23, —N(R23)C(O)N(R23)2, —N(R23)S(O)2(R23), —S(O)R23, —S(O)2R23, —S(O)2N(R23)2, —NO2, ═S, ═O, and —CN;
• R20, R21, R22, and R23, are each independently selected at each occurrence from (d), (e), and (f):
• (d) hydrogen;
• (e) C1-6 alkyl optionally substituted with one or more substituents independently selected from halogen, —O—C1-6 alkyl, —O—C1-6 haloalkyl, —NH2, —NO2, ═O, —CN, C3-10 carbocycle and 3- to 10-membered heterocycle, wherein each C3-10 carbocycle and 3- to 10-membered heterocycle are optionally substituted with one or more substituents independently selected from:
• halogen, —OH, —O—C1-6 alkyl, —O—C1-6 haloalkyl, —NH2, —NO2, ═O, and —CN;
• and
• (f) C3-10 carbocycle and 3- to 10-membered heterocycle optionally substituted with one or more substituents independently selected from:
• halogen, —OH, —O—C1-6 alkyl, —O—C1-6 haloalkyl, —NH2, —NO2, ═O, and —CN;
• x is selected from 0, 1, 2, 3, and 4;
• y is selected from 0, 1, 2, 3, and 4;
• and
• z is selected from 0, 1, 2, 3, 4 and 5;
• wherein
• at least one of x or y is selected from 1, 2, 3, and 4.