Botulinum toxin formulations and methods for intranasal delivery thereof for the treatment of allergic rhinitis

A method for intranasal delivery of a formulation comprising Botulinum toxin for the treatment of allergic rhinitis, the method comprising:

• impregnating an exterior of an absorbent tip of an applicator with the formulation prior to insertion of the applicator into a nasal cavity, the applicator comprising a rigid rod having the absorbent tip at a distal end thereof;
• initially targeting the nasal cavity by using the applicator to target inside a nasal vestibule, septal walls and a dorsal roof of the nasal cavity, wherein the initial targeting is performed from 2 minutes to 8 minutes;
• inserting the applicator straight into the nasal cavity of a patient beneath the lower turbinates to target the nasal- or nasopharynx-associated lymphoid tissue (NALT) and the eustachian tube opening zone of the nasopharynx within the nasal cavity with the absorbent tip;
• and
• massaging the absorbent tip back-and-forth across the NALT and the eustachian tube opening zone, wherein the NALT and the eustachian tube opening zone are targeted for more than 10 minutes.