Transdermal delivery complex using metal-organic framework and triblock copolymer

A composite for transdermal delivery comprising a metal-organic framework, a triblock copolymer of polyethylene glycol (PEG)-polycaprolactone (PCL)-polyethylene glycol (PEG), and a cosmetically active ingredient;

• wherein the metal-organic framework is a zeolite imidazolate framework (ZIF)-8;
• wherein the cosmetically active ingredient is one or more selected from the group consisting of a moisturizer, a whitening agent, an anti-wrinkle agent, a UV blocking agent, a hair growth promoter, vitamin or a derivative thereof, amino acid or peptide, an anti-inflammatory agent, an acne therapeutic agent, a microbicide, female hormone, a keratolytic agent and a natural product;
• wherein an imine group of the ZIF-8 is bonded with the triblock copolymer of PEG-PCL-PEG to form the composite for improving a transdermal delivery effect;
• and
• wherein 0.01 to 20 parts by weight of the triblock copolymer of PEG-PCL-PEG is comprised based on 10 parts by weight of the metal-organic framework.