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US 12,465,278 B2Granted
Multiplexed sweat extraction and sensing wearable device for normalized and time-sequential sweat analysis
AssigneeThe Regents of the University of California
InventorSam Emaminejad
Life of this patent
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Abstract
A wearable device for multiplexed sweat analysis includes a sensing module. The sensing module includes multiple compartments, including a first compartment configured to induce sweat and sense a target analyte, and a second compartment configured to induce sweat and sense the target analyte.
Claims19
A wearable device for sweat analysis, comprising:
- a sensing module including multiple compartments, including:
- a first compartment configured to induce sweat and sense a first level of a target analyte in the sweat induced by the first compartment;
- and
- a second compartment configured to induce sweat and sense a second level of the target analyte in the sweat induced by the second compartment;
- a current source respectively coupled to provide current to the first and second compartments;
- a signal conditioner coupled between the current source and the first and second compartments, wherein the signal conditioner is configured to condition the current from the current source so as to provide first and second respective different currents to the first and second compartments in accordance with first and second respective different sweat secretion rates;
- and
- a processor configured to derive a measurement of a blood level of the target analyte from multiple sweat measurements comprising multiple ones of the sensed first and second levels of the target analyte obtained from the first and second compartments,
- wherein the processor is configured to derive the blood level of the target analyte from the multiple sweat measurements of the target analyte using a model of a relationship between the blood level of the target analyte and a sweat level of the target analyte under a plurality of sweat induction conditions.
6 more elements
A wearable device for sweat analysis, comprising:
- a first sensing region including
- a first pair of iontophoresis electrodes and a first secretory agonist-containing hydrogel layer adjacent to the first pair of iontophoresis electrodes;
- and
- a first sensor configured to sense a first level of a target analyte in sweat induced in the first sensing region;
- a second sensing region including
- a second pair of iontophoresis electrodes and a second secretory agonist-containing hydrogel layer adjacent to the second pair of iontophoresis electrodes;
- and
- a second sensor configured to sense a second level of the target analyte in sweat induced in the second sensing region;
- a current source respectively coupled to provide current to the first and second sensing regions;
- a signal conditioner coupled between the current source and the first and second sensing regions, wherein the signal conditioner is configured to condition the current from the current source so as to provide first and second different currents to the first and second sensing regions in accordance with respective first and second different sweat secretion rates;
- and
- a processor connected to the first sensing region and the second sensing region, wherein the processor is configured to derive a measurement of a blood level of the target analyte from multiple sweat measurements comprising multiple ones of the sensed first and second levels of the target analyte obtained from the first and second sensing regions,
- wherein the processor is configured to derive the blood level of the target analyte from the multiple sweat measurements of the target analyte using a model of a relationship between the blood level of the target analyte and a sweat level of the target analyte under a plurality of sweat induction conditions.
10 more elements
Dependencies are inferred from the claim text.