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US 12,465,045 B2Granted
Lung perfusion solution, and use thereof for the ex-vivo preservation of a mammalian lung
AssigneeUniversity College Dublin, National University of Ireland, Dublin
InventorsPaul McLoughlin, Simon Coyle Rowan
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Abstract
A lung perfusion solution comprises a base solution comprising a physiological mixture of electrolytes and buffers, 3.5-5.5% (w/v) a first macromolecule having a molecular weight of 40-100 KDa, and an amount of a second, high molecular weight, macromolecule sufficient to adjust the relative viscosity of the solution to 2.0-3.0.
Claims19
An organ perfusion solution comprising:
- a base solution comprising a physiological mixture of electrolytes and buffers;
- and 3.5-5.5% w/v a first macromolecule having a molecular weight of 40-100 kDa and an amount of a second, high molecular weight, macromolecule having a molecular weight of 350-600 kDa to adjust the relative viscosity of the organ perfusion solution to 2.1-2.7.
An organ perfusion solution comprising a base solution comprising a physiological mixture of electrolytes and buffers;
- and 3.5-5.5% w/v FICOLL PM70, and an amount of FICOLL PM400 to adjust the relative viscosity of the organ perfusion solution to 2.1-2.7.
Dependencies are inferred from the claim text.