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US 12,461,099 B2Granted
Immunoreactive polypeptides
AssigneeResearch Development Foundation
InventorsJere McBride, David H. Walker
Life of this patent
Estimating the term…
Abstract
Methods and compositions for diagnosing and vaccinating against Ehrlichia chaffeensis are provided.
Claims8
A method of detecting antibodies that specifically bind an Ehrlichia organism in a test sample, comprising:
- (a) contacting an isolated polypeptide of Ecaj_0919, Ecaj_0073, Ecaj_0104, Ecaj_0663, A77 (SEQ ID NO:22), A62 (SEQ ID NO:17), A56 (SEQ ID NO:16), A19 (SEQ ID NO:6), A50 Ech_0700;
- SEQ ID NO:
- 28), A51 (SEQ ID NO:13), A14 (SEQ ID NO:4), A63 (SEQ ID NO:18), A34 (SEQ ID NO:9), A9 (SEQ ID NO:3), A42 (Ech_0240;
- SEQ ID NO:11), with the test sample, under conditions that allow peptide-antibody complexes to form;
- (b) detecting the peptide-antibody complexes;
- wherein the detection of the peptide-antibody complexes is an indication that antibodies specific for an Ehrlichia organism are present in the test sample, and wherein the absence of the peptide-antibody complexes is an indication that antibodies specific to an Ehrlichia organism are not present in the test sample.
3 more elements
A method of identifying an Ehrlichia infection in a mammalian subject comprising:
- (a) contacting a biological sample from the subject with an isolated polypeptide of Ecaj_0919, Ecaj_0073, Ecaj_0104, Ecaj_0663, A77 (SEQ ID NO:22), A62 (SEQ ID NO:17), A56 (SEQ ID NO:16), A19 (SEQ ID NO:6), A50 (Ech 0700;
- SEQ ID NO:
- 28), A51 (SEQ ID NO:13), A14 (SEQ ID NO:4), A63 (SEQ ID NO:18), A34 (SEQ ID NO:9), A9 (SEQ ID NO:3), or A42 (Ech 0240;
- SEQ ID NO:11), under conditions that allow peptide-antibody complexes to form;
- and (b) detecting the peptide-antibody complexes;
- wherein the detection of the peptide-antibody complexes is an indication that the subject has an Ehrlichia infection.
3 more elements
Dependencies are inferred from the claim text.