Fungal cell with improved protein production capacity
AssigneeMelt & Marble AB
InventorsMingtao Huang, Anastasia Krivoruchko, Florian David, Jens Nielsen
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Abstract
The present invention related to the provision of genetically modified fungal cells, such as yeast cells with an improved ability for producing and secreting different recombinant proteins. The improved ability is obtained by disruption in intracellular transport between the Golgi and the endosome. In particular embodiments, the disruption is achieved by downregulation or deletion of the gene encoding a Tda3p homolog. The fungal cell and method of the invention would allow for large-scale production of recombinant proteins in fungal cells.
Claims15
A fungal cell, wherein said fungal cell is genetically modified for
- reduced expression of any protein,
- and
- said fungal cell comprises a gene encoding a recombinant protein.
Dependencies are inferred from the claim text.