Lipid-encapsulated dual-cleaving endonuclease for DNA and gene editing

Abstract

Disclosed herein are methods to edit genes, for example by administering a chimeric nuclease to a cell or organism without the use of a viral vector. Some methods herein include editing DNA of a cell by contacting the cell with a nuclease comprising a Cas9 sequence, where the nuclease edits the DNA of the cell.

Dependencies are inferred from the claim text.