Nitric oxide-releasing hyperbranched compounds as antibacterial scaffolds and methods pertaining thereto

A hyperbranched nitric oxide (NO) donating compound, comprising:

• a linking group comprising any one or more of Formulas A, B, C, or D:
• wherein,
• indicates an attachment to another portion of the hyperbranched NO donating compound;
• X1, X2, X3, and X4 are independently selected from the group consisting of —NH—, —N(Ra)—, —O—, and —S—;
• wherein, at least one instance of X1, X2, X3, and X4 is —N(Ra)—;
• wherein each instance of Ra is selected from a NO donating moiety, —H, an optionally substituted C1-C6 alkyl group, or an optionally substituted polyether having 1 to 6 to repeat units;
• wherein, in at least one instance of Formula A, the secondary amine of Formula A is directly bound to a NO donating moiety or at least one instance of Ra is a NO donating moiety, wherein the NO donating moiety is selected from the group consisting of:
• R1, R2, and R3 are independently selected from the group consisting of —RbN(Rc)Rd—(N(Rc))n—Rb—, —Rb(ORd—)nO—Rb—, and C1-C6 alkyl;
• wherein each instance of Rc is independently selected from a NO donating moiety, —H, an optionally substituted C1-C6 alkyl group, or an optionally substituted poly ether having 1 to 6 repeat units;
• wherein Rb is a single bond or an optionally substituted C1-C6 alkylene group;
• wherein Ra is an optionally substituted C1-C6 alkylene group;
• wherein n is an integer selected from 0, 1, 2, 3, 4, 5, or 6;
• wherein, where R2 is present, at least one instance of Rd comprises the —C(O)—(CH2)2—X3— group;
• wherein, where R3 is present, at least one instance of Rd comprises the —C(O)—(CH2)2—X3— group and at least one instance of Rd comprises the —C(O)—(CH2)2—X4— group;
• and,
• wherein the hyperbranched compound does not comprise an aminoglycoside or glycoside unit.