Proteins comprising CD3 antigen binding domains and uses thereof
AssigneeJanssen Biotech, Inc.
InventorsRaymond Brittingham, Scott R. Brodeur, Rajkumar Ganesan, Jaclyn Hoover, Steven A. Jacobs, Colleen M. Kane, Jinquan Luo, Sanjaya Singh, Fang Yi, Adam Zwolak, Triveni K. Bhatt, Michael Dennis Feldkamp, Sherry Lynn La Porte
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Abstract
The disclosure provides antigen binding domains that bind cluster of differentiation 3 (CD3) protein, comprising the antigen binding domains that bind CD3ε, polynucleotides encoding them, vectors, host cells, methods of making and using them.
Claims50
An isolated protein comprising an antigen binding domain that binds to cluster of differentiation 3ε (CD3ε), wherein the antigen binding domain that binds CD3ε comprises a heavy chain complementarity determining region (HCDR) 1, a HCDR2 and a HCDR3 of a heavy chain variable region (VH) of SEQ ID NO:
- 23 and a light chain complementarity determining region (LCDR) 1, a LCDR2 and a LCDR3 of a light chain variable region (VL) of SEQ ID NO:
- 28.
Dependencies are inferred from the claim text.