Cancer gene therapy drug
AssigneeNational University Corporation Kobe University
InventorsToshiro Shirakawa, Naoto Kunimura, Koichi Kitagawa
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Abstract
Provided is a novel cancer gene therapeutic means. More specifically, provided is a nucleic acid having a structure in which (A) a nucleic acid encoding a protein having a CD44 extracellular function, (B) a nucleic acid encoding a protein having a Notch core region function, and (C) a nucleic acid encoding a protein having an HIF-3α4 function are linked in the order of (A)-(B)-(C).
Claims20
A nucleic acid having a structure in which (A) a nucleic acid encoding a protein having a CD44 extracellular function, (B) a nucleic acid encoding a protein having a Notch core region function, and (C) a nucleic acid encoding a protein having an HIF-3α4 function are linked in an order of (A)-(B)-(C).
A nucleic acid having a structure in which nucleic acid (A), nucleic acid (B), and nucleic acid (C) are linked in an order of (A)-(B)-(C);
- nucleic acid (A) being:
- (a-1):
- a nucleic acid consisting of a base sequence of SEQ ID NO:
- 1, of
- nucleic acid (B) being:
- (b-1):
- a nucleic acid consisting of a base sequence of SEQ ID NO:
- 2, or
- and
- nucleic acid (C) being:
- (c-1):
- a nucleic acid consisting of a base sequence of SEQ ID NO:
- 3.
A nucleic acid that is:
- consisting of the base sequence of SEQ ID NO:
- 4.
Dependencies are inferred from the claim text.