Back to results
US 12,459,976 B2Granted
Peptides and their use in diagnosis
AssigneeBiotome Pty Ltd.
InventorBror Samuel Lundin
Life of this patent
Estimating the term…
Abstract
There is provided novel peptides for use in diagnosis of CagA+ H. pylori infection or the prediction of risk for gastric cancer. The peptides bind antibodies from CagA+ H pylori patients with high specificity and sensitivity, and can be used for example in a diagnostic kit.
Claims8
A method of diagnosis comprising the steps of:
- a) providing a sample from a subject having, or suspected of having, a Helicobacter pylori infection and/or increased risk of gastric cancer in the subject,
- b) contacting said sample with a peptide comprising an amino acid sequence selected from the group consisting of:
- SEQ ID NO:
- 26, SEQ ID NO:
- 171, SEQ ID NO:
- 172, SEQ ID NO:
- 173, SEQ ID NO:
- 174, SEQ ID NO:
- 175, SEQ ID NO:
- 176, SEQ ID NO:
- 177, SEQ ID NO:
- 178, SEQ ID NO:
- 179, SEQ ID NO:
- 180, SEQ ID NO:
- 181, SEQ ID NO:
- 182, SEQ ID NO:
- 183, SEQ ID NO:
- 184, SEQ ID NO:
- 185, SEQ ID NO:
- 280, and SEQ ID NO:
- 281, said peptide consisting of at most 25 amino acids, and
- c) detecting specific binding of antibodies in the sample to the peptide, wherein presence of antibodies in the sample which specifically bind to the peptide is indicative of Helicobacter pylori infection and/or increased risk of gastric cancer in the subject.
19 more elements
A method of detecting H. pylori CagA-binding antibodies in a sample from a subject, the method comprising contacting a biological sample with a peptide comprising an amino acid sequence selected from the group consisting of:
- SEQ ID NO:
- 26, SEQ ID NO:
- 171, SEQ ID NO:
- 172, SEQ ID NO:
- 173, SEQ ID NO:
- 174, SEQ ID NO:
- 175, SEQ ID NO:
- 176, SEQ ID NO:
- 177, SEQ ID NO:
- 178, SEQ ID NO:
- 179, SEQ ID NO:
- 180, SEQ ID NO:
- 181, SEQ ID NO:
- 182, SEQ ID NO:
- 183, SEQ ID NO:
- 184, SEQ ID NO:
- 185, SEQ ID NO:
- 280, and SEQ ID NO:
- 281, said peptide consisting of at most 25 amino acids and detecting binding of antibodies in the sample to the peptide.
16 more elements
Dependencies are inferred from the claim text.