Protease-activated contrast agents for in vivo imaging
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsMatthew S. Bogyo, Martijn Verdoes, Leslie Ofori, Nimali P. Withana
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Abstract
Compounds useful as contrast agents in image-guided surgery are provided. The compounds comprise a latent cationic lysosomotropic fragment that is detectable upon cleavage by lysosomal proteases within treated tissues, particularly within tumors and other diseased tissues. Also provided are compositions comprising the compounds and methods for using the compounds, for example in dynamically monitoring protease activity in vivo during image-guided tumor resection surgery.
Claims19
A method of labeling a tissue in an animal comprising the step of:
- administering a composition to the animal, wherein the composition comprises:
- a compound and a pharmaceutically acceptable carrier;
- wherein the compound has a formula (I)
- wherein D is a detectable element comprising a fluorescent label;
- Q is a QSY quencher or QC-1;
- L0 and L1 is each independently a C2-8 alkyl linker;
- AA2 is an aralkyl amino acid side chain;
- U is O;
- R is an aralkyl group.
Dependencies are inferred from the claim text.