Compounds and methods of use thereof as antibacterial agents
AssigneeMerck Sharp & Dohme Corp.
InventorsBrendan M. Crowley, Philippe Nantermet, David Olsen, Takao Suzuki
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Abstract
Disclosed are dihydroisoxazole compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein A, E, and R1 are as defined herein. Also disclosed are compositions which comprise at least one of these dihydroisoxazole compounds, methods for inhibiting growth of mycobacterial cells as well as a method of treating mycobacterial infections by Mycobacterium tuberculosis comprising administering a therapeutically effective amount of these dihydroisoxazole compounds and/or a pharmaceutically acceptable salt thereof, or a composition comprising such compound and/or salt.
Claims32
A compound, or a pharmaceutically acceptable salt thereof, having the structure:
A compound, or a pharmaceutically acceptable salt thereof, having the structure:
A compound having the structure:
A compound, or a pharmaceutically acceptable salt thereof, having the structure:
A compound having the structure:
Dependencies are inferred from the claim text.