Benzothiophene derivative regulator, preparation method therefor and use thereof

A compound of formula (IV-A), a stereoisomer thereof or a pharmaceutically acceptable salt thereof:

• wherein:
• is selected from the group consisting of single bond and a double bond;
• R2 is selected from the group consisting of hydrogen, cyano, halogen, C1-6 alkyl, C1-6 haloalkyl and C3-6 cycloalkyl;
• or, two R2 on the same or different carbon atoms are bonded to form a C3-8 cycloalkyl or 3 to 8 membered heterocyclyl, wherein the C3-8 cycloalkyl or 3 to 8 membered heterocyclyl is optionally further substituted by one or more substituents selected from the group consisting of deuterium, C1-6 alkyl, halogen, amino, oxo, thioxo, cyano, hydroxy, C3-8 alkoxy, C3-8 haloalkoxy and C3-8 hydroxyalkyl;
• R3 is selected from the group consisting of hydrogen, halogen, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, hydroxy, cyano, C2-6 alkenyl and C2-6 alkynyl;
• R4 is selected from the group consisting of hydrogen and C1-6 alkyl;
• R5 is selected from the group consisting of C1-6 alkyl, C3-8 cycloalkyl, 3 to 8 membered heterocyclyl, C6-14 aryl, 5 to 14 membered heteroaryl, —(CH2)n1Raa, —C(O)Raa, —C(O)NRaaRbb, —C(O)(CH2)n1Raa, —C(O)NRaa(CH2)n1Rbb, —S(O)2Raa, —(CH2)n1S(O)(═NRaa)Rbb, —S(O)m1NRaaRbb and —C(O)ORaa, wherein the C1-6 alkyl, C3-8 cycloalkyl, 3 to 8 membered heterocyclyl, C6-14 aryl and 5 to 14 membered heteroaryl are each optionally further substituted by one or more substituents selected from the group consisting of cyano, halogen, C1-6 alkyl and C1-6 alkoxy;
• or, R4 and R5 are bonded to form a 3 to 8 membered heterocyclyl or 5 to 14 membered heteroaryl, which is optionally further substituted by one or more substituents selected from the group consisting of C1-6 alkyl, halogen, amino, oxo, thioxo, cyano, hydroxy, C3-8 alkoxy, C3-8 haloalkoxy, C3-8 hydroxyalkyl, —C(O)Rcc and —C(O)NRccRdd;
• Raa and Rbb are each independently selected from the group consisting of hydrogen, amino, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C3-8 cycloalkyl, 3 to 8 membered heterocyclyl, C6-14 aryl and 5 to 14 membered heteroaryl, wherein the amino, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C3-8 cycloalkyl, 3 to 8 membered heterocyclyl, C6-14 aryl and 5 to 14 membered heteroaryl are each optionally further substituted by one or more substituents selected from the group consisting of halogen, hydroxy, cyano, oxo, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C3-8 cycloalkyl, 3 to 8 membered heterocyclyl, C6-14 aryl and 5 to 14 membered heteroaryl;
• or, Raa and Rbb together with the adjacent nitrogen atom are bonded to form a 4 to 10 membered heterocyclyl, which is optionally further substituted by one or more substituents selected from the group consisting of halogen, hydroxy, cyano, oxo, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy and C1-6 hydroxyalkyl;
• Rcc and Rdd are each independently selected from the group consisting of hydrogen, amino, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C3-8 cycloalkyl, 3 to 8 membered heterocyclyl, C6-14 aryl and 5 to 14 membered heteroaryl, wherein the amino, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C3-8 cycloalkyl, 3 to 8 membered heterocyclyl, C6-14 aryl and 5 to 14 membered heteroaryl are each optionally further substituted by one or more substituents selected from the group consisting of halogen, hydroxy, cyano, oxo, C1-6 alkyl, C1-6 haloalkyl and C1-6 alkoxy;
• y is 0, 1, 2, 3 or 4;
• z is 0, 1, 2, 3 or 4;
• m is 1 or 2;
• and
• n1 is 0, 1, 2 or 3;
• wherein the compound of formula (IV-A) does not comprise compounds