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US 12,459,930 B2Granted
Compounds for the inhibition of unregulated cell growth
AssigneeGodavari Biorefineries Limited
InventorsSandip Gavade, Maithili Athavale, Sangeeta Srivastava, Prashant Kharkar
Life of this patent
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Abstract
The present invention discloses compounds for inhibition of uncontrolled cell proliferation particularly cancer stem cells. Particularly, the invention relates to compounds of Formula I to XXII for the treatment of cancer.
Claims21
A compound of Formula I:
- wherein,
- E and Z is selected from C and N;
- Q is O;
- R5 is —H or —Cl;
- R6 and R7 each independently is selected from —H, or R6 and R7 together form a heterocyclic ring;
- R8 is —H;
- R10 is selected from
- R′ is selected from —H and alkoxy;
- R11 and R12 each independently is selected from —H, or R11 and R12 can be substituted or unsubstituted lactone;
- R is selected from
- or salts thereof;
- and
- n is selected from 2, 4 and 6.
10 more elements
A compound of Formula Ia:
- wherein,
- E and Z is C;
- Q is O;
- R5 is —H;
- R6 and R7 each independently is —H;
- R8 is —H;
- R10 is
- R11 and R12 each independently is —H;
- R is selected from
- n is 1-10.
7 more elements
A pharmaceutical composition comprising any of the compounds selected from a group consisting of
- along with at least one pharmaceutically acceptable excipient and optionally at least one active agent.
A compound selected from a group consisting of
- for use in the treatment or inhibition of uncontrolled cell growth in cancer or for use in effectively targeting cancer cells including cancer stem cells.
Dependencies are inferred from the claim text.