Compounds for treating conditions related to oxidative stress

A compound of formula (I), or a pharmaceutically acceptable salt, hydrate, solvate, optical isomer, or combination thereof,

• wherein:
• represents single or double bond
• R1 and R2 is selected form the group consisting of —H, —C1-20 alkyl, C2-20-alkenyl, and C2-20-alkynyl, optionally mono-, di- or tri-substituted with halogen, substituted and unsubstituted Aryl, substituted and unsubstituted heteroaryl (mono and bicyclic)
• R3 is selected from the group consisting of —H, —C1-20 alkyl, C2-20-alkenyl, and C2-20-alkynyl, wherein R3 may be substituted by one or more A;
• aryl and heteroaryl
• R4 is selected from the group consisting of —H, —C1-20 alkyl, C2-20-alkenyl, and C2-20 alkynyl, wherein R4 may be substituted by one or more A;
• R5 is selected from the group consisting of (a) aryl, (b) heteroaryl, (c) —C1-2 alkyl-aryl, and (d) —C1-2 alkyl-heteroaryl,
• wherein A is aryl or heteroaryl;
• wherein the aryl of choices (a) and (c), and the heteroaryl of choices (b) and (d), are optionally mono-, di- or tri-substituted with substituents selected from the group consisting of halogen, —C1-6 alkyl, —CF3, —OCF3, —C1-6 alkoxy, —C3-6 cycloalkoxy, halo-C1-6 alkyl, aryl, heteroaryl, heterocyclo, —C3-6 cycloalkyl, and —C3-6 cycloalkenyl;
• provided at least one out of the R1, R2, R3, R4 and R5 is selected from the group consisting of
• wherein X, Y, Z are selected from the group consisting of —H, methyl, ethyl, propyl, butyl, substituted or unsubstituted aryl and heteroaryls;
• n is an integer selected from 0-18 and E is phosphorous or nitrogen atom.