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US 12,459,876 B2Granted
One-step kit-based synthesis of 2-deoxy-2-[18F]fluoro-D-sorbitol
AssigneeThe Johns Hopkins University
InventorsSanjay K. Jain, Filipa Mota, Alvaro A. Ordonez
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Abstract
A self-contained kit and method for the on-demand synthesis of 2-deoxy-2-[18F]fluoro-D-sorbitol (18F-FDS) from commercially available 2-deoxy-2-[F18]fluoroglucose (18F-FDG) is disclosed.
Claims17
A method for preparing 2-deoxy-2-[18F]fluoro-D-sorbitol (18F-FDS), the method comprising:
- (a) providing an aliquot of 2-deoxy-2-[18F]fluoro-D-glucose (18F-FDG);
- (b) contacting the aliquot of 18F-FDG with a solid-supported borohydride source to form 18F-FDS;
- and
- (c) purifying the 18F-FDS by contacting the 18F-FDS formed in step (b) with a cation exchange resin comprising PS—H+ or an anion exchange resin comprising PSHCO3.
1 more element
Dependencies are inferred from the claim text.