Adsorbent and a kit containing said adsorbent in a column
AssigneeGlycoprobe AB
InventorKurt Nilsson
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Abstract
An adsorbent comprising at least two types of covalently bound antigens having the ability to bind at least one component present in a blood flow or blood plasma flow passing through said adsorbent is disclosed, as well as a column containing said adsorbent, a kit containing said column in a sealed plastic bag, a method for the production of said kit, a method for reduction or elimination of undesired blood group specific antibodies or autoimmune antibodies in connection with autoimmune diseases, a method for treatment of myasthenia gravis, and a method for treatment of rheumatoid arthritis.
Claims11
An adsorbent comprising at least two types of covalently bound antigens having the ability to bind at least one component present in a blood flow or blood plasma flow passing through said adsorbent, wherein said at least two types of antigen comprises at least one linear peptide and at least one cyclic peptide, and optionally at least one protein,
- wherein optionally a spacer is provided between the peptide and the adsorbent,
- wherein said at least one linear peptide is at least one linear citrullinated peptide and wherein said at least one cyclic peptide is at least one cyclic citrullinated peptide, wherein said at least one cyclic citrullinated peptide is derived from a peptide sequence having the ability to bind to certain autoantibodies found in blood from patients with rheumatoid arthritis (RA), wherein said peptide sequence is derived from a protein selected from filaggrin, fibrin, fibrinogen, vimentin, and enolase.
Dependencies are inferred from the claim text.