Back to results
US 12,458,807 B2Granted
Apparatus and methods for phase-agnostic stimuli
AssigneeResearch Development Foundation
InventorsDavid Paydarfar, Joshua Chang, Sara A. Santos, Varun K. Sridhar
Life of this patent
Estimating the term…
Abstract
Apparatus and methods for applying a phase-agnostic stimuli are disclosed herein. Certain embodiments include methods and apparatus that are configured to receive a detected signal from a subject and transmit a stimulation signal that is configured to optimize a response signal without regard to the phase of the detected signal.
Claims17
An apparatus for applying a therapeutic treatment to a subject, the apparatus comprising:
- a stimulation electrode;
- and
- a programmable arbitrary waveform generator, wherein the programmable arbitrary waveform generator is configured to:
- receive a detected biological oscillator signal from the subject;
- transmit a first stimulation signal to the subject via the stimulation electrode, wherein the first stimulation signal is transmitted at a phase of the detected biological oscillator signal;
- receive a response signal from the subject;
- and
- transmit a second stimulation signal to the subject via the stimulation electrode, wherein the second stimulation signal is configured to optimize the response signal without regard to the phase of the detected biological oscillator signal by suppressing oscillation in the detected biological oscillator signal while minimizing an electrical current level of the second stimulation, wherein:
- the second stimulation signal is generated using an extrema distortion algorithm, a deep learning algorithm or a reinforcement learning algorithm.
6 more elements
An apparatus for applying a therapeutic treatment to a subject, the apparatus comprising:
- a detection module;
- a transmission module;
- and
- a waveform generator, wherein the waveform generator is configured to:
- receive a detected biological oscillator signal from the subject via the detection module;
- transmit a first stimulation signal to the subject via the transmission module;
- receive a first response biological oscillator signal from the subject via the detection module;
- transmit a second stimulation signal to the subject via the transmission module;
- and
- receive a second response biological oscillator signal from the subject via the detection module, wherein:
- the second stimulation signal is configured to optimize the first response signal by suppressing oscillation in the second response biological oscillator signal while minimizing an electrical current level of the second stimulation signal;
- and
- the first stimulation signal and the second stimulation signal are applied in a phase agnostic manner, wherein:
- the second stimulation signal is generated using an extrema distortion algorithm, a deep learning algorithm or a reinforcement learning algorithm.
11 more elements
A method of treating a disease in a mammalian subject, the method comprising:
- receiving an oscillating electrical signal from a subject;
- applying a first stimulation signal to the subject at a phase window of the oscillating electrical signal, wherein the first stimulation signal modifies the oscillating electrical signal from the subject to produce a response signal;
- receiving the response signal from the subject;
- and
- applying a second stimulation signal to the subject, wherein the second stimulation signal is configured to optimize the response signal without regard to the phase window of the oscillating electrical signal by suppressing oscillation in the response signal while minimizing an electrical current level of the second stimulation, wherein:
- the second stimulation signal is generated using an extrema distortion algorithm, a deep learning algorithm or a reinforcement learning algorithm.
3 more elements
A method of applying a therapeutic treatment to a subject, comprising:
- applying an electrical stimulation to the subject;
- receiving feedback from the subject in response to said electrical stimulation;
- adjusting said electrical stimulation based at least in part on said feedback, where the adjustment includes a change of the electrical stimulation waveform and comprises one or more of a change to phase, amplitude, timing, duration, shape;
- and
- applying the adjusted electrical stimulation to the subject, wherein:
- the adjusted electrical stimulation is generated using an extrema distortion algorithm, a deep learning algorithm or a reinforcement learning algorithm;
- and
- the adjusted electrical stimulation suppresses oscillation in the feedback while minimizing an electrical current level of the adjusted electrical stimulation.
5 more elements
Dependencies are inferred from the claim text.