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US 12,458,698 B2Granted
Expansion of γδ T cells, compositions, and methods of use thereof
AssigneesKing's College London, GammaDelta Therapeutics Ltd
InventorsRichard Beatson, Adrian Hayday, Oliver Nussbaumer, Richard Woolf, Maria Luisa Iannitto, Natalie Mount
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Abstract
The present invention provides methods of expanding γδ T cells from a non-haematopoietic tissue source. Further provided are compositions of expanded γδ T cells and methods of using the expanded γδ T cells (e.g., a part of an adoptive T cell therapy).
Claims20
An expanded population of γδ T cells obtained by a method comprising the steps of:
- (i) providing a population of γδ T cells obtained from a non-haematopoietic tissue, wherein the non-haematopoietic tissue is skin or gut;
- and
- (ii) culturing the population of γδ T cells in the presence of:
- a. I1-2 or IL-9;
- b. IL-15;
- and
- c. IL-21;
- for at least 5 days in amounts effective to produce an expanded population of γδ T cells.
5 more elements
Dependencies are inferred from the claim text.