African swine fever virus vaccine
AssigneeStichting Wageningen Research
InventorsPetrus Theodorus Johannes Willemsen, Bernardus Petrus Hubertus Peeters
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Abstract
The invention is directed to a recombinant nucleic acid molecule comprising an expression cassette encoding a polyepitope comprising T-cell antigens from proteins of African Swine Fever Virus. The invention further relates to a viral particle, comprising said recombinant nucleic acid molecule, and to a viral particle comprising B-cell antigens of African Swine Fever Virus. The invention further relates to methods of stimulating an immune response in a pig comprising administering the recombinant molecule of the invention, and/or the viral particle of the invention, to the pig in an amount effective to induce an immune response.
Claims14
A vaccine comprising an effective immunizing amount of a recombinant nucleic acid molecule, comprising an expression cassette encoding a polyepitope comprising T-cell antigens from proteins of African Swine Fever Virus comprising 2-50 nonapeptides as T-cell antigens selected from SEQ ID NOs:
- 2-14 and 16-21, wherein the T-cell antigens are separated by spacers that contain signals for proteasome cleavage, selected from spacer sequences ARY, NQF, RRW, AQW, and/or SEQ ID NOs:
- 22-28, and wherein said vaccine further comprises a viral particle comprising B-cell antigens of African Swine Fever Virus, selected from proteins p30, p54, p72, EP402R, A104R and/or B602L of African Swine Fever Virus, wherein the recombinant molecule comprises the nucleotide sequence of SEQ ID NO:
- 33.
Dependencies are inferred from the claim text.