Back to results
US 12,458,687 B2Granted
Wound debridement systems
AssigneeRegenics AS
InventorHenrik Lund
Life of this patent
Estimating the term…
Abstract
The present invention provides compositions and methods for wound debridement and healing. The debridement compositions preferably comprise a metalloprotease enzyme such as a choriolytic enzyme.
Claims17
A method of debriding a wound comprising contacting the wound with an effective amount of a metalloprotease, wherein the metalloprotease is selected from the group consisting of a low choriolytic enzyme (LCE), a high choriolytic enzyme (HCE) and combinations thereof.
A kit or system for treating a wound comprising:
- a first container comprising a metalloprotease in an amount effective to remove devitalized tissue from a wound, wherein the metalloprotease is selected from the group consisting of a low choriolytic enzyme (LCE), a high choriolytic enzyme (HCE) and combinations thereof;
- and
- a second container comprising a wound healing agent.
A pharmaceutical or cosmetic composition comprising:
- a recombinant low choriolytic enzyme (LCE) that is at least 90% identical to SEQ ID NO:1 and has LCE activity;
- and
- one or more pharmaceutically or cosmetically acceptable excipients and/or diluents,
- wherein the composition is a gel, cream, ointment, lotion, foam, non-aqueous solution, spray, salve, stick, soap, powder, film, emulsion, suspension or dispersion and
- wherein the recombinant LCE exhibits metalloprotease activity in an in vitro assay.
2 more elements
Dependencies are inferred from the claim text.